ACES Cas: 7365-82-4 phofo e tšoeu ea kristale 99% N-(Carbamoylmethyl)taurine
Nomoro ea lethathamo | XD90108 |
Lebitso la Sehlahiswa | ACES (N-(2-Acetamido) -2-aminoethanesulfonic acid) |
CAS | 7365-82-4 |
Foromo ea limolek'hule | Setšoantšo sa C4H10N2O4S |
Boima ba Molek'hule | 182.2 |
Lintlha tsa polokelo | Ambient |
Khoutu ea Lekhetho e Kopantsoeng | 29241900 |
Tlhaloso ea Sehlahisoa
Ketapele | <5ppm |
pH | 3.5 - 4,5 |
Litaba tsa Metsi | <0.5% |
Tšepe | <5ppm |
Masalla a ho Ignition | <0.1% |
Ponahalo | Phofo e tšoeu ea kristale |
A260 (0.1M metsi) | <0.020 |
A280 (metsi a 0.1M) | <0.010 |
Assay (Titration) ka motheo o omisitsoeng | >99% |
Sepheo sa thuto ena e ne e le ho bapisa katleho ea valproate le haloperidol ho fokotsa boemo ba ho ferekana ho bakuli ba amehileng lefapheng la tšohanyetso.Re ile ra abela bakuli ba 80 ba ferekaneng haholo hore ba amohele sodium valproate (20 mg/kg) kapa intramuscular haloperidol (5 mg/1 ml).Ho ferekana ho ile ha lekanyetsoa qalong le metsotso ea 30 ka mor'a ente ea pele e sebelisang Agitation-Calmness Evaluation Scale (ACES), Positive and Negative Syndrome Scale-Excited Component subscale, le Agitated Behavior Scale.Bakeng sa bakuli ba 80 ba tšoaroang ka sodium valproate, tekanyo ea ± SD e ne e le 1541.5 ± 286 mg (range 940-2400).Likarolo tse bolelang ka mor'a ho kenella ACES ho tloha qalong ho ea ho 30 min ka mor'a ho kenngoa ha lithethefatsi e ne e le 4.73 (SD = 1.93) bakeng sa sehlopha sa valproate le 5.45 (SD = 2.09) bakeng sa sehlopha sa haloperidol (P = 0.028).Ha ho na phapang e kholo e ileng ea hlokomeloa ho latela liphetoho tse bolelang 30 min ka mor'a ho kenella bakeng sa litekanyo tse peli tse eketsehileng tsa ho ferekana.Palo e kholoanyane ea bakuli sehlopheng sa haloperidol e ile ea e-ba le sedation e matla (36.2%, P <0.001) le matšoao a extrapyramidal (8.7%, P = 0.007) ha a bapisoa le sehlopha sa valproate (2.5% bakeng sa sedation e matla, ha ho mokuli bakeng sa matšoao a extrapyramidal).Liphuputso li fana ka maikutlo a hore maemong a ts'ebetso ea kliniki ea mafu a kelello a tšohanyetso, valproate e kenang ka har'a methapo e sebetsa hantle joalo ka haloperidol ho fokotsa ho ferekana, ka boemo bo botle ba polokeho.