Lihlahisoa

(4R-Cis) -1,1-Dimethylethyl-6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol -1-yl]ethyl] -2,2-dimethyl-1,3-dioxane-4-acetate ke motsoako o nang le lik'hemik'hale tse rarahaneng.Le hoja tlhahisoleseding e tobileng mabapi le tšebeliso ea motsoako ona e ka 'na ea fokotseha, re ka buisana ka mekhoa ea eona e ka sebelisoang ho latela likarolo tsa eona tsa sebopeho le litšobotsi tse tloaelehileng tsa metsoako e tšoanang.Ho ba teng ha karolo ea dioxane ka har'a motsoako ona ho fana ka maikutlo a hore e ka' na ea e-ba le lisebelisoa tsa solvent kapa ea sebelisoa. joalo ka ntho e etsang solubilizing.Dioxane ke motsoako o tloaelehileng, haholo-holo k'hemistri ea tlhaho, kaha e kopane le metsi 'me e na le ho qhibiliha ho hotle bakeng sa mefuta e mengata ea limolek'hule tsa tlhaho.Ho ba teng ha karolo ea dioxane ka har'a motsoako ona ho bontša hore e ka 'na ea e-ba le lintho tse tšoanang tsa ho qhibiliha.Ho feta moo, likarolo tsa sebopeho sa motsoako ona, tse kang lihlopha tsa fluorophenyl le phenylamino carbonyl, li fana ka maikutlo a ts'ebetso e ka bang teng ea likokoana-hloko.Ho kenngoa ha fluorine ka har'a metsoako ea manyolo ho ka ntlafatsa thepa ea bona ea pharmacokinetic, ho ka eketsa matla a bona kapa bioavailability.Ho ba teng ha sehlopha sa phenylamino carbonyl ho ka 'na ha bontša monyetla oa ho sebelisana le lipakane tsa likokoana-hloko, mohlomong tse lebisang liphellong tsa phekolo.Ho itšetlehile ka likarolo tsena tsa meralo, ho ka etsahala hore motsoako ona o ka ba le likopo ho k'hemistri ea meriana kapa nts'etsopele ea lithethefatsi.E ka hlahlojoa e le motsoako o ka bang teng oa lead bakeng sa nts'etsopele ea meriana e mecha e lebisitseng mafu a itseng.Leha ho le joalo, ke habohlokoa ho hlokomela hore lithuto tse ling lia hlokahala ho fumana hore na e hlile e sebetsa joang, ho kenyelletsa le katleho ea eona, mokhoa oa ho sebetsa, le litla-morao tse ka 'nang tsa e-ba teng.Ho phaella ho k'hemistri ea meriana, motsoako ona oa nitronyl kapa pyrrole moiety o ka fana ka maikutlo a tšebeliso ea lisebelisoa tsa saense. kapa e le karolo ea motsoako oa lik'hemik'hale.Li-derivatives tsa Nitronyl le pyrrole li 'nile tsa batlisisoa bakeng sa tšebeliso ea tsona e ka sebelisoang e le li-conductor tsa organic, li-catalyst, kapa li-block tsa mohaho bakeng sa mehaho e rarahaneng haholoanyane.Leha ho le joalo, likopo tsena li ne li tla hloka lipatlisiso tse eketsehileng le ho ntlafatsa mekhoa ea ho kopanya.Ka kakaretso, motsoako (4R-Cis) -1,1-Dimethylethyl-6--[2-(4-fluorophenyl) -5-(1- methylethyl) -3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetate e bonts'a monyetla oa ho sebelisoa k'hemistri ea meriana, mahlale a thepa, kapa motsoako oa lik'hemik'hale.Leha ho le joalo, ho bohlokoa ho etsa lipatlisiso tse batsi ho lekola thepa ea eona, ho nts'etsapele litsela tse loketseng tsa ho kopanya, le ho tseba hore na e sebelisoa joang lefapheng le leng le le leng.