Lihlahisoa

(3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy) -6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one, e tsejoang hape e le TBDMS-protected tetrahydro-2H-pyran -2-one, ke motsoako o atisang ho sebelisoa ho organic synthesis le e le sehlopha se sireletsang tšimong ea k'hemistri.Kopo e le 'ngoe ea bohlokoa ea TBDMS-protected tetrahydro-2H-pyran-2-one ke tšebeliso ea eona e le mohaho oa mohaho oa ho kopanya. ea limolek'hule tse rarahaneng tsa lintho tse phelang.Motsoako o na le libaka tse ngata tse sebetsang tse ka bang le liphetoho tse fapaneng tsa lihlopha tse sebetsang.Sehlopha se sireletsang sa TBDMS (tert-butyldimethylsilyl) se teng ka molek'hule se fana ka botsitso 'me se lumella phetoho e khethehileng ea lihlopha tse itseng tse sebetsang.Ho feto-fetoha hona ho etsa hore TBDMS e sirelelitsoeng ka tetrahydro-2H-pyran-2-e le 'ngoe e be ea bohlokoa lipakeng tsa tlhahiso ea lihlahisoa tsa tlhaho, meriana, le lik'hemik'hale tse ling tse ntle. Tšebeliso e 'ngoe ea bohlokoa ea TBDMS-protected tetrahydro-2H-pyran-2-one ke eona karolo e le sehlopha se sireletsang lino tse tahang le li-amine ho organic synthesis.Sehlopha sa TBDMS se ka eketsoa ka khetho ho lihlopha tsa hydroxyl kapa amino, ka ho li pata hantle nakong ea mehato e fapaneng ea karabelo.Tšireletso ena e thibela liketso tse sa batleheng le ho netefatsa hore liphetoho tse lakatsehang li etsahala libakeng tse lakatsehang.Hang ha likarabo tse lakatsehang li phethiloe, sehlopha sa TBDMS se ka tlosoa habonolo, se pepesa sehlopha sa pele sa hydroxyl kapa amino ntle le ho ama mesebetsi e meng ea molek'hule.TBDMS-protected tetrahydro-2H-pyran-2-one e boetse e fumana kopo e le moemeli oa tšireletso bakeng sa lik'habohaedreite.E lumella tšireletso e khethehileng ea lihlopha tsa hydroxyl ka limolek'hule tsa tsoekere nakong ea karabelo ea glycosylation, e nolofalletsang motsoako oa li-glycans tse rarahaneng le li-glycosides.Leano lena la tšireletso le bohlokoa ka ho khetheha lik'hemik'hale tsa lik'hemik'hale tsa lik'habohaedreite, moo lihlopha tse ngata tsa hydroxyl li leng teng 'me ho hlokahala regioselectivity e khethehileng.Ho feta moo, tetrahydro-2H-pyran-2-one e sirelelitsoeng ke TBDMS e sebelisoa ha ho etsoa li-polymers tse sebetsang hantle.Motsoako o ka kenyelletsoa meahong ea polymer, e fana ka libaka tse sebetsang bakeng sa liphetoho tse ling le karabelo e hokahanyang.Sena se nolofalletsa ho thehoa ha thepa ea polymer e nang le thepa le mesebetsi e hlophisitsoeng, e kang botsitso bo ntlafetseng, biocompatibility, le ho lokolloa ha lithethefatsi tse laoloang.Qetellong, (3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy) -6 -((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one, kapa TBDMS-protected tetrahydro-2H-pyran-2-one, ke motsoako o nang le mekhoa e mengata e nang le mefuta e fapaneng ea likopo tsa organic synthesis, haholo-holo e le mohaho oa mohaho le sehlopha se sireletsang. .Bokhoni ba eona ba ho khetha ho sireletsa lihlopha tse sebetsang le ho tsamaisa liphetoho tse rarahaneng tsa limolek'hule ho etsa hore e be sesebelisoa sa bohlokoa lefapheng la k'hemistri.Patlisiso e tsoelang pele le tlhahlobo ea ts'ebeliso ea eona e ka utolla ts'ebeliso e 'ngoe hape ea kenya letsoho ntlafatsong ea k'hemistri ea maiketsetso le mahlale a lintho tse bonahalang.