Lihlahisoa

Acetoxy Empagliflozin, eo hape e tsejoang e le empagliflozin acetate, ke mofuta o fetotsoeng oa sethethefatsi sa lefu la tsoekere empagliflozin.Empagliflozin ke ea sehlopha sa lithethefatsi tse tsejoang e le sodium-glucose co-transporter 2 (SGLT2) inhibitors, tseo haholo-holo li sebelisetsoang ho laola lefu la tsoekere la mofuta oa 2. Empagliflozin e sebetsa ka ho thibela SGLT2, protheine e ikarabellang bakeng sa ho khutlisa tsoekere ka liphio.Ka ho thibela protheine ena, (3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy) -6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one ke motsoako oa lik'hemik'hale o rarahaneng o nang le lebitso le lelele la lik'hemik'hale.E oela tlas'a sehlopha sa triMethylsilyloxy pyranones, tse sebelisoang haholo lits'ebetsong tse fapaneng tsa saense le indasteri.E 'ngoe ea litšebeliso tsa bohlokoa tsa (3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy) -6-( (triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one e le sehlopha se sireletsang ho organic synthesis.Lihlopha tse sireletsang ke lihlopha tse sebetsang tsa nakoana tse sebelisetsoang ho sireletsa libaka tse itseng tse sebetsang ka molek'hule nakong ea karabelo ea lik'hemik'hale.Tabeng ea (3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy) -6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one, lihlopha tsa triMethylsilyloxy li sebetsa e le lihlopha tse sireletsang. .Nakong ea karabelo, lihlopha tsena li sireletsa lihlopha tse itseng tse sebetsang hore li se ke tsa etsahalloa ke maikutlo a sa batleheng, e leng se lumellang hore maikutlo a batloang a tsoele pele hantle.Ka mor'a hore karabelo e phethoe, lihlopha tsa triMethylsilyloxy li ka tlosoa habonolo, li senola lihlopha tsa pele tse sebetsang. Methyl)tetrahydro-2H-pyran-2-one e ka har'a motsoako oa metsoako ea lintho tse phelang.E ka sebelisoa e le motheo oa ho haha ​​​​mehaho e rarahaneng haholoanyane.Lintho tsa eona tse ikhethang tsa lik'hemik'hale le ts'ebetso ea ts'ebetso e etsa hore e be sesebelisoa sa bohlokoa ho nts'etsopele ea mekhatlo e mecha ea lik'hemik'hale.Litsebi tsa lik'hemik'hale li ka sebelisa (3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy) -6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one ho hlahisa lihlopha tse itseng tse sebetsang kapa ho theha molek'hule e itseng. scaffolds ho ithuta mesebetsi ea likokoana-hloko ea metsoako kapa ho hlahisa meriana e mecha.Ho phaella moo, motsoako ona o ka fumana lits'ebetso lefapheng la saense ea lintho tse bonahalang.Ho ba teng ha eona e le sehlopha se sebetsang ka har'a molek'hule ho ka fana ka thepa e itseng e lakatsehang ho thepa.Ka mohlala, e ka 'na ea ntlafatsa ho qhibiliha ka har'a lihlapolli tse itseng kapa ea ntlafatsa thepa ea ho etsa filimi, ea etsa hore e be molemo ho lira kapa li-adhesive.(3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy) -6-(( triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one ke motsoako o ikhethileng o nang le ts'ebeliso e fapaneng makaleng a fapaneng a saense le indasteri.Bokhoni ba eona ba ho sebetsa e le sehlopha se sireletsang le ho sebetsa e le mohaho oa mohaho oa k'hemistri ea maiketsetso, hammoho le mekhoa ea eona e ka sebelisoang ho saense ea lintho tse bonahalang, e etsa hore e be karolo ea bohlokoa ho nts'etsopele ea limolek'hule tse ncha le lisebelisoa.Leha ho le joalo, ts'ebeliso le ts'ebeliso e nepahetseng e ka fapana, ho latela litlhoko le lipheo tsa morero o itseng oa saense kapa indasteri.