Lihlahisoa

(3R,4R) -1-(tert-Butoxycarbonyl) -4-methylpyrrolidine-3-carboxylic acid, eo hape e tsejoang e le Boc-4-methylproline, ke motsoako oa lik'hemik'hale o sebelisoang haholo tšimong ea organic synthesis, haholo-holo tlhahiso ea li-peptide le peptidomimetics bakeng sa likopo tse sa tšoaneng.E 'ngoe ea litšebeliso tse ka sehloohong tsa Boc-4-methylproline ke sehlopha se sireletsang bakeng sa sehlopha sa amino sa amino acid nakong ea peptide synthesis.Lihlopha tse sireletsang ke liphetoho tsa nakoana tse sireletsang lihlopha tse itseng tse sebetsang tsa limolek'hule ho thibela liketso tse sa batleheng nakong ea ts'ebetso ea maiketsetso.Ka peptide synthesis, Boc-4-methylproline e sebelisoa e le sehlopha se sireletsang bakeng sa sehlopha sa amine, se lumellang hore ho be le sehokelo se khethiloeng sa li-amino acid tse ling ho theha tatellano e lakatsehang ea peptide. tlhaho ea metsoako e fapaneng e nang le mesebetsi e ka bang teng ea baeloji.Joaloka motsoako oa chiral, o na le stereocenter, e hlahisang li-enantiomers tse peli: (3R,4R) -Boc-4-methylproline le (3S,4S) -Boc-4-methylproline.Enantiomer e 'ngoe le e' ngoe e ka bonts'a thepa e fapaneng ea pharmacological le litšebelisano le sepheo sa baeloji.Ka ho sebelisa Boc-4-methylproline e le ntho e qalang, litsebi tsa k'hemistri li ka fumana mefuta e mengata ea metsoako ea chiral bakeng sa ho sibolloa ha lithethefatsi le nts'etsopele.Lik'hemik'hale tsena li 'nile tsa batlisisoa bakeng sa bokhoni ba tsona ba ho phekola likokoana-hloko tse fapaneng, ho akarelletsa le libaktheria, livaerase le lisele tsa mofetše.Ka ho fetola sebopeho sa Boc-4-methylproline le ho hlahloba lihlahisoa tsa eona, bafuputsi ba ka hlahloba bokhoni ba bona e le metsoako ea lead kapa limolek'hule tsa scaffold bakeng sa moralo oa lithethefatsi. ho thehoeng ha peptidomimetics.Peptidomimetics ke metsoako e etsisang sebopeho le ts'ebetso ea li-peptide empa e na le botsitso bo ntlafalitsoeng le thepa ea pharmacokinetic.Boc-4-methylproline e ka sebetsa e le moaho oa moralo le tlhahiso ea peptidomimetics, e lumellang nts'etsopele ea litlhare tse ncha tse nang le bioavailability e ntlafetseng le sepheo se tobileng. 4-methylpyrrolidine-3-carboxylic acid, kapa Boc-4-methylproline, ke motsoako o nang le mekhoa e mengata e sebelisoang haholo ho organic synthesis.Karolo ea eona e le sehlopha se sireletsang peptide synthesis, hammoho le thepa ea eona ea chiral, e e etsa sebaka sa bohlokoa sa ho aha bakeng sa ho theha li-peptide, peptidomimetics le metsoako ea chiral.Lintho tse tsoang ho Boc-4-methylproline li batlisisoa bakeng sa mesebetsi ea bona e ka bang teng ea likokoana-hloko, tse kenyeletsang thepa e thibelang likokoana-hloko, antiviral le anticancer.Lipatlisiso tse tsoelang pele le mekhoa e mecha ea ho sebelisa Boc-4-methylproline moralong oa lithethefatsi li kenya letsoho ho nts'etsopele ea lisebelisoa tse ncha tsa phekolo le ho ntlafatsa kutloisiso ea rona ea mekhoa e rarahaneng ea likokoana-hloko.