Lihlahisoa

Motsoako (2R,3R,4R,5S,6S) -2-(acetoxymethyl)-6-(4-chloro-3-(4-ethoxybenzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate ke molek'hule e rarahaneng ea lintho tse phelang e nang le ts'ebeliso e ka bang teng libakeng tse 'maloa tsa lipatlisiso tsa k'hemistri le tsa meriana.Tsebeliso e le 'ngoe ea motsoako ona e ka har'a motsoako oa lintho tse phelang.Ho ba teng ha lihlopha tse ngata tse sebetsang, ho kenyelletsa acetoxymethyl, chloro, le ethoxybenzyl, ho fana ka mekhoa e fapaneng ea ho laola le ho fetola molek'hule.Litsebi tsa k'hemistri li ka sebelisa motsoako ona e le ntho ea ho qala ho kopanya metsoako e rarahaneng ea lintho tse phelang, tse kang li-intermediate tsa meriana kapa lihlahisoa tsa tlhaho tsa lihlahisoa.Ka ho khetha ka leano le ho fetola lihlopha tse itseng tse sebetsang, bafuputsi ba ka fetola thepa ea motsoako le ho ntlafatsa thepa ea eona e lakatsehang, joalo ka ts'ebetso ea likokoana-hloko kapa ho qhibiliha ha metsi.Tsebeliso e 'ngoe e ka bang teng ea (2R,3R,4R,5S,6S) -2-(acetoxymethyl) - 6-(4-chloro-3-(4-ethoxybenzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate e lutse ka k'hemistri ea meriana.Sebopeho sa motsoako se na le likarolo tse 'maloa tse atisang ho fumanoa limolek'hule tse sebetsang ka meriana, tse kang lesale la pyran le sehlopha se nkhang hamonate sa benzyl.Bafuputsi ba meriana ba ka hlahloba bokhoni ba meriana ea motsoako ona ka ho ithuta ho sebelisana ha oona le lipakane tsa likokoana-hloko, ho etsa lithuto tsa likamano tsa sebopeho le ts'ebetso, le ho hlahloba katleho ea oona ea phekolo.Ho ba teng ha sehlopha sa triacetate ho ka boela ha fana ka melemo e eketsehileng, e kang botsitso bo ntlafetseng, ho eketseha ha lipophilicity, kapa ho matlafatsa lera la membrane, e leng thepa e lakatsehang ho nts'etsopele ea lithethefatsi.Ho feta moo, motsoako o ikhethang oa stereochemistry (2R,3R,4R,5S,6S) e kenya letsoho ho bokhoni ba eona e le mohaho oa ho haha ​​​​chiral ka asymmetric synthesis.Litsi tsa chiral tse teng ka har'a molek'hule li fana ka monyetla oa ho lokisa metsoako e hloekileng ea enantiomerically, e leng bohlokoa tlhahisong ea meriana le lik'hemik'hale tsa temo.Litsebi tsa lik'hemik'hale tsa lintho tse phelang li ka sebelisa motsoako ona e le lisebelisoa tse qalang tsa chiral kapa tsa li kenya ka tsela e rarahaneng ea ho kopanya lihlahisoa ho fumana lihlahisoa tse hloekileng tsa enantiomerically.Bafuputsi ba lokela ho nka mehato e nepahetseng ea tšireletso le ho netefatsa bohloeki le sebopeho sa motsoako pele ba sebelisoa. Ka kakaretso, (2R,3R,4R,5S,6S) -2-(acetoxymethyl) -6-(4-chloro-3-(4-ethoxybenzyl) )phenyl) tetrahydro-2H-pyran-3,4,5-triyl triacetate e na le ts'episo ea ho ba motsoako o feto-fetohang ho organic synthesis, chemistry ea meriana, le asymmetric synthesis.Ka lihlopha tsa eona tse ngata tse sebetsang le stereochemistry e ikhethang, e fana ka menyetla ea nts'etsopele ea likhomphutha tse ncha tse nang le ts'ebeliso e ka bang teng mafapheng a fapaneng a mahlale, ho kenyeletsoa ho sibolloa ha lithethefatsi, saense ea lintho tse bonahalang, le biology ea lik'hemik'hale.