Lihlahisoa

2,3-Difluoro-4-ethoxybenzeneboronic acid ke motsoako o fumanang thuso likarolong tse 'maloa tsa k'hemistri, haholo-holo ho organic synthesis le chemistry ea meriana.Ka sebopeho sa eona se ikhethang le ts'ebetso ea ts'ebetso, e fetohile mohaho oa bohlokoa bakeng sa ho theha limolek'hule tse rarahaneng tsa limolek'hule le metsoako ea meriana.E 'ngoe ea lisebelisoa tse ka sehloohong tsa 2,3-Difluoro-4-ethoxybenzeneboronic acid e itšetlehile ka tšebeliso ea eona ea ho kopanya li-cross-coupling.Litšebelisano tsa li-cross-coupling, tse kang li-couplings tsa Suzuki-Miyaura le Buchwald-Hartwig, ke mekhoa e matla ea ho haha ​​​​litlamo tsa carbon-carbon le carbon-heteroatom.Lits'ebetsong tsena, 2,3-Difluoro-4-ethoxybenzeneboronic acid e ka sebetsa e le karolo ea boronate ester, e sebetsanang le li-electrophiles tse sa tšoaneng (mohlala, aryl halides, vinyl halides) tlas'a tšusumetso ea li-catalyst tse loketseng.Sena se nolofalletsa ho qaptjoa ha metsoako e sa tšoaneng e nang le thepa ea biologically e sebetsang, e kang li-agent tsa meriana kapa agrochemicals.Ho feta moo, ho ba teng ha liathomo tsa fluorine ho 2,3-Difluoro-4-ethoxybenzeneboronic acid ho ka fana ka thepa e molemo ho limolek'hule tse hlahisoang.Phatlalatso ea fluorine e ka ntlafatsa botsitso, lipophilicity, le boemo ba pharmacokinetic ba metsoako ea organic, ea ba etsa bakhethoa ba sebetsang hantle ba lithethefatsi.Ka hona, ts'ebeliso ea leano la 2,3-Difluoro-4-ethoxybenzeneboronic acid e le selelekela sa motsoako oa metsoako e kang ea lithethefatsi e ka fana ka phihlello ea limolek'hule tsa fluorinated tse nang le ts'ebetso e ntlafetseng ea likokoana-hloko le lintho tse lakatsehang tsa physicochemical. Ho phaella moo, sehlopha sa ethoxy se teng ho 2 ,3-Difluoro-4-ethoxybenzeneboronic acid e fana ka mekhoa e mengata e fapaneng ea lisebelisoa tsa maiketsetso.E ka ba tlas'a liphetoho tsa nucleophilic substitution, e lumellang ho kenngoa ha lihlopha tse sa tšoaneng tse sebetsang sebakeng sa ethoxy.Sena se nolofalletsa ho tlosoa ha motsoako ho fetola thepa ea oona ka sepheo se itseng kapa ho hlahisa lintlha tse eketsehileng tsa mefuta-futa ho laeborari synthesis bakeng sa ho sibolloa ha lithethefatsi. k'hemistri ea meriana.Ho nka karolo ha eona ho li-cross coupling reactions, ho kenyelletsoa ha liathomo tsa fluorine, le ho tsoa sebakeng sa ethoxy ho e etsa sesebelisoa sa bohlokoa bakeng sa kaho ea metsoako e fapaneng ea lintho tse phelang tse nang le ts'ebeliso ea meriana e ka bang teng.Tšebeliso ea eona e thusa ho kopanya limolek'hule tse rarahaneng le lilaebrari bakeng sa ho sibolloa ha lithethefatsi le ho fana ka phihlelo ea metsoako ea fluorinated e nang le thepa e ntlafetseng.