Lihlahisoa

1-(4-Methoxyphenyl) -7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl] -4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine -3-carboxylic acid ethyl ester ke motsoako o rarahaneng oa lik'hemik'hale o bontšitseng bokhoni libakeng tse sa tšoaneng tsa lik'hemik'hale tsa meriana le ho sibolloa ha lithethefatsi.Mona ke tlhaloso ea tšebeliso ea eona ka mantsoe a ka bang 300. Motsoako ona, oo hangata o bitsoang derivative ea ethyl ester ea 1- (4-Methoxyphenyl) -7-oxo-6-[4-(2-oxopiperidin-1-yl) phenyl] -4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid, ke ea sehlopha sa pyrazolo [3,4-c] pyridine derivatives.Lintho tsena tse nkiloeng li hohetse tlhokomelo ea ho sibolloa ha lithethefatsi ka lebaka la bokhoni ba tsona libakeng tse sa tšoaneng tsa phekolo.E 'ngoe e ka sebelisoang ea motsoako ona e teng lefapheng la lipatlisiso tse khahlanong le kankere.Li-derivatives tsa pyrazolo [3,4-c] pyridine li bonts'itse ts'ebetso e ts'episang ea ho thibela ho ata ha mefuta e mengata ea lisele tsa mofetše.Bokhoni ba bona ba ho thibela litsela tse itseng tse amehang kholong ea hlahala le ho phela ho etsa hore e be batho ba ka bang teng bakeng sa nts'etsopele ea lithethefatsi tse thibelang mofetše.Liphuputso tse ling li hlokahala ho hlahloba mokhoa oa ts'ebetso le ho hlahloba katleho ea lik'hemik'hale maemong a pele le a kliniki.Ho feta moo, motsoako ona o bontšitse tšepiso e le moemeli oa antibacterial.E bonts'itse ts'ebetso khahlano le mefuta e fapaneng ea libaktheria, ho kenyeletsoa libaktheria tsa Gram-positive le Gram-negative.Bokhoni ba ho shebana le mefuta e mengata e fana ka maikutlo a bokhoni ba eona ba ho loants'a libaktheria tse hananang le lithethefatsi, tse fetohileng bothata bo boholo ba bophelo bo botle ba lefats'e.Liphuputso tse ling li loketse ho batlisisa mokhoa oa eona oa ketso le ho hlahloba katleho ea eona ho loantša tšoaetso ea baktheria.Ho phaella moo, lihlahisoa tsa pyrazolo [3,4-c] pyridine, ho kopanyelletsa le motsoako ona, li bontšitse bokhoni ba ho phekola mafu a ho ruruha le a autoimmune.Ho ruruha ho phetha karolo ea bohlokoa maemong a fapaneng a kang ramatiki ea rumatoid le psoriasis.Li-derivatives tsena li bontšitse thepa e khahlanong le ho ruruha ka ho fetola litsela tse khethehileng tse amehang karabelong ea ho ruruha.Sena se fana ka maikutlo a bokhoni ba bona e le lisebelisoa tsa phekolo bakeng sa ho laola ho ruruha ho sa foleng le maloetse a amanang le tsona.Ho feta moo, motsoako ona o bontšitse mosebetsi tsamaisong ea methapo e bohareng (CNS).E 'nile ea batlisisoa ka bokhoni ba eona ho mafu a methapo a kang lefu la Alzheimer's le Parkinson's disease.Motsoako o ka fetola li-receptor le li-enzyme tse amehang ho tsoeleng pele ha mafu, tse ka fanang ka litlamorao tsa neuroprotective.Leha ho le joalo, ho hlokahala lipatlisiso tse eketsehileng ho utloisisa ka botlalo mokhoa oa eona oa ho sebetsa le ho hlahloba katleho ea eona ho phekola mathata ana a rarahaneng.Ka kakaretso, 1- (4-Methoxyphenyl) -7-oxo-6- [4- (2-oxopiperidin-1-) yl)phenyl] -4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester e na le ts'episo libakeng tse' maloa tsa kalafo, ho kenyelletsa anti-cancer, antibacterial, anti-inflammatory. , le mathata a CNS.Monyetla oa eona o ka bokhoni ba eona ba ho shebisisa litsela le li-receptor tse amehang maemong ana.Leha ho le joalo, lipatlisiso tse ling le lipatlisiso lia hlokahala ho hlahloba bokhoni ba eona ka botlalo, ho ntlafatsa thepa ea eona, le ho lekola polokeho le katleho ea eona maemong a kliniki.