Lihlahisoa

1-(4-Fluorophenyl) piperazine dihydrochloride, eo hape e tsejoang e le 4-FPP, ke motsoako oa lik'hemik'hale o fumanang mefuta e fapaneng ea likopo lefapheng la meriana le lipatlisiso.Sebopeho sa eona se ikhethang sa molek'hule se nang le athomo ea fluorine le selikalikoe sa piperazine se etsa hore e be ea bohlokoa bakeng sa merero e fapaneng, ho tloha ho nts'etsopele ea lithethefatsi ho ea lipatlisisong tsa saense. meriana e mengata ea phekolo.Ka lebaka la bokhoni ba eona ba ho etsa liphetoho tsa lik'hemik'hale, e thusa ho theha batho ba bacha ba nang le ts'ebetso ea meriana.Ho ba teng ha karolo ea piperazine mohahong oa eona ho molemo ka ho khetheha bakeng sa nts'etsopele ea meriana e lebisitseng tsamaiso ea methapo e bohareng, e kang li-antipsychotics, li-anti-depressants, le li-anti-anxiety agents.Ho feta moo, 1-(4-Fluorophenyl)piperazine dihydrochloride hangata e sebelisoa lipatlisiso tsa mahlale ho batlisisa lits'ebetso tse fapaneng tsa baeloji.Joalo ka molek'hule ea lisebelisoa tse ngata, e sebelisoa ho ithuta ho tlama li-receptor, litšebelisano tsa methapo ea methapo, le litlamorao tsa lithethefatsi lits'ebetsong tse itseng 'meleng.Bafuputsi ba sebelisa motsoako ona ho manolla mekhoa ea ts'ebetso ea lithethefatsi tse fapaneng, ho hlakisa li-receptor subtypes, le ho hlahloba litsela tsa phetisetso ea matšoao.Ka ho fumana kutloisiso e tebileng ea lits'ebetso tsena, bo-ramahlale ba ka ntšetsa pele tsebo e mabapi le mathata a mangata a methapo ea kutlo le ea kelello, ba bula tsela bakeng sa nts'etsopele ea maano a morao-rao a kalafo. Ho feta moo, 1-(4-Fluorophenyl) piperazine dihydrochloride e sebelisoa e le selelekela sa bohlokoa tlhahiso ea li-radioligands bakeng sa positron emission tomography (PET).Li-radioligands tse thehiloeng ho motsoako ona, tse ngotsoeng ka li-isotopi tse nang le mahlaseli a kotsi, li lumella pono e sa hlaseleng le quantification ea mekhoa e khethehileng ea lik'hemik'hale 'meleng oa motho.Mekhoa e joalo ea ho nahana e fana ka lintlha tsa bohlokoa mabapi le kabo ea li-receptor, ho lula le ho teteana ha li-receptor, ho thusa ho lekola maemo a fapaneng a methapo le ho thusa ho nts'etsopele ea mekhoa ea kalafo e lebisitsoeng. kaha e nkuwa e le ntho e ka bang kotsi.Mehato e nepahetseng ea tšireletso le lisebelisoa tsa ts'ireletso li lokela ho sebelisoa ho fokotsa kotsi ea ho pepeseha ka tsietsi kapa ho tšoaroa hampe.Ts'ebeliso ea eona e kenyelletsa motsoako oa lithethefatsi, boithuto ba lits'ebetso tsa baeloji, le nts'etsopele ea li-radioligands bakeng sa litšoantšo tsa PET.Tsebo ea thepa ea motsoako le ts'ebetso e hlokolosi ke ea bohlokoa ho netefatsa polokeho le ho thusa ho kenya letsoho ho nts'etsopele ea mahlale le bongaka.