Lihlahisoa

1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine ke motsoako oa lik'hemik'hale o nang le mefuta e mengata e mengata ea lik'hemik'hale tsa meriana le nts'etsopele ea meriana. , haholo-holo ho sibolloeng ha lithethefatsi.Ho ba teng ha sehlopha sa hydroxymethylpyridinyl ho fana ka maikutlo a litšebelisano tse ka bang teng le lipheo tse itseng tsa tlhaho, joalo ka li-enzyme kapa li-receptor.Litsebi tsa k'hemistri ea meriana li ka ntlafatsa sebopeho sa motsoako ona ho matlafatsa kamano ea ona e tlamang le khetho ho lipheo tsa tlhaho tse lakatsehang.Ka ho fetola likarolo tsa phenyl le piperazine, bafuputsi ba ka lokisa metsoako ea metsoako ea physicochemical le pharmacokinetics, e leng se ka lebisang ho ntlafatso ea matla a lithethefatsi le ho fokotsa litla-morao tse sa batleheng.Kopo e 'ngoe e ka sebelisoang ea 1-(3-Hydroxymethylpyridin-2-yl) -4 -methyl-2-phenylpiperazine e sebakeng sa neuropharmacology.Sebopeho sa motsoako ona se fana ka maikutlo a ho sebelisana ho ka khonehang le li-receptors tsamaisong ea methapo e bohareng, e ka 'nang ea lebisa liphellong tsa phekolo ea mafu a kelello.Mohlala, e ka hlahlojoa e le mokhethoa oa ho fetola phetisetso ea methapo maemong a kang ho tšoenyeha, khatello ea maikutlo, kapa schizophrenia.Bafuputsi ba ka 'na ba batlisisa mokhoa oa ts'ebetso ea motsoako' me ba etsa lithuto tsa pele le tsa kliniki ho hlahloba bokhoni ba eona ba phekolo.Ho feta moo, likarolo tsa sebopeho sa motsoako ona li ka etsa hore e tšoanelehe bakeng sa likopo tsa ho fana ka lithethefatsi.Lihlopha tsa eona tsa hydrophobic phenyl le methyl li fana ka maikutlo a bokhoni ba ho tšela li-membrane tsa lipid, ho li nolofalletsa ho lebisa li-enzyme kapa litsela tsa intracellular.Thepa ena e na le molemo bakeng sa ho hlahisa lithethefatsi tse hlokang ho kenella ka har'a lisele le ho fana ka litlamorao tsa tsona ho sepheo se itseng sa intracellular.Ka ho fetola sebopeho sa motsoako, litsebi tsa meriana ea meriana li ka ntlafatsa bioavailability ea eona, ho ntlafatsa botsitso ba eona, le ho hlahisa mekhoa e sebetsang ea ho fana ka lithethefatsi.Ke habohlokoa ho hlokomela hore tšebeliso ea 1-(3-Hydroxymethylpyridin-2-yl) -4-methyl-2 -phenylpiperazine lits'ebetsong tsena tse ka bang teng e hloka litlhahlobo tse matla tsa pele tsa bongaka le tsa bongaka ho netefatsa polokeho, katleho, le litekanyetso tse nepahetseng.Lithuto tse pharaletseng tsa meriana le tsa toxicological lia hlokahala ho utloisisa litlamorao tsa eona lits'ebetsong tse fapaneng tsa baeloji le ho fumana litlamorao life kapa life tse ka bang teng. likopo tse ka bang teng ho k'hemistri ea meriana le nts'etsopele ea lithethefatsi.E na le ts'episo ea moralo oa lithethefatsi tse ncha, haholo-holo libakeng tsa neuropharmacology le phano ea lithethefatsi.Ho hlokahala lipatlisiso tse ling ho hlahloba litšebelisano tsa eona tse ikhethileng, mokhoa oa ts'ebetso, le bokhoni ba kalafo, ho bula tsela bakeng sa katleho e ka bang teng kalafong ea mafu le mathata a fapaneng.