1-(3-Carboxypyrid-2-yl)-2-phenyl-4-methyl-piperazine CAS: 61338-13-4
| Nomoro ea lethathamo | XD93391 |
| Lebitso la Sehlahiswa | 1-(3-Carboxypyrid-2-yl)-2-phenyl-4-methyl-piperazine |
| CAS | 61338-13-4 |
| Foromo ea molek'hulela | C17H19N3O2 |
| Boima ba Molek'hule | 297.35 |
| Lintlha tsa polokelo | Ambient |
Tlhaloso ea Sehlahisoa
| Ponahalo | Phofo e tšoeu |
| Assay | 99% mets |
1-(3-Carboxypyrid-2-yl) -2-phenyl-4-methyl-piperazine, eo hape e tsejoang e le CPPMP, ke motsoako oa lik'hemik'hale o nang le mohaho o rarahaneng o nang le mekhoa e sa tšoaneng e ka sebelisoang lefapheng la lik'hemik'hale tsa meriana. ea CPPMP e kalafong ea mafu a methapo ea kutlo.Ho ba teng ha sehlopha sa carboxypyridyl ho bonts'a bokhoni ba eona ba ho sebelisana le li-receptor tse itseng tsa neuronal tsamaisong ea methapo e bohareng.Ho shebana le li-receptor tsena ho ka fetola tšebetso ea methapo ea kutlo, e ka lebisang litlamoraong tsa kalafo maemong a kang khatello ea maikutlo, matšoenyeho, kapa mathata a neurodegenerative.Ho hlokahala lipatlisiso tse eketsehileng ho hlahloba litšebelisano tse khethehileng tsa li-receptor le mokhoa oa ts'ebetso ea CPPMP e le ho ntlafatsa bokhoni ba eona e le moemeli oa phekolo bakeng sa mafu a methapo ea methapo.Litsebi tsa lik'hemik'hale tsa meriana li ka fetola likarolo tse fapaneng tsa sebopeho sa eona ho ntlafatsa thepa ea eona ea meriana kapa ho shebana le litsela tse itseng tsa tlhaho.Ka ho ntlafatsa sebopeho sa CPPMP, bafuputsi ba ka etsa li-derivatives ka mekhoa e ntlafetseng ea khetho, potency, le ts'ireletso ea ts'ireletso, ho etsa hore e be baemeli ba loketseng bakeng sa lithethefatsi tse lebisang maloetse a sa tšoaneng.Ho feta moo, CPPMP's phenyl le lihlopha tsa methyl li fana ka thepa ea hydrophobic, e ka 'nang ea e-ba molemo ho hlahisa lithethefatsi tse ka tšelang. lisele tsa lisele le ho fihlella lipakane tsa intracellular.Tšobotsi ena e ka sebelisoa ho theha lithethefatsi tse ncha tse lebisang ka ho khetheha li-enzyme kapa litsela tsa intracellular, ho fana ka menyetla ea ho kenella kalafo mafung a kang kankere kapa mathata a metabolic.Ho phaella moo, likarolo tse ikhethang tsa meralo ea CPPMP li lumella hore ho be le tsoelo-pele ea li-prodrugs kapa mekhoa ea ho fana ka lithethefatsi. .Ka ho fetola sehlopha sa eona sa carboxypyridyl, motsoako o ka etsoa hore o tsitsitse haholoanyane kapa o fokotse chefo ka mokhoa oa oona oa tlhaho, ha o ntse o tsamaisa ka katleho karolo e sebetsang ea lithethefatsi sebakeng se lakatsehang sa ketso.Liphetoho tse joalo li ka ntlafatsa bioavailability le katleho ea phekolo ea motsoako.Ho lokela ho hlokomeloa hore tšebeliso ea CPPMP lits'ebetsong tsena tse ka 'nang tsa e-ba teng ke khopolo-taba 'me e tla hloka lipatlisiso le nts'etsopele ea bohlokoa pele e sebelisoa.Ho feta moo, litšebeliso tsohle tsa CPPMP li ne li tla hloka ho latela liprothokholo le litataiso tse thehiloeng ho netefatsa ho sebetsana hantle le ho fokotsa kotsi.Qetellong, 1-(3-Carboxypyrid-2-yl) -2-phenyl-4-methyl-piperazine, kapa CPPMP. , e na le ts'episo ea lits'ebetso tse fapaneng tsa k'hemistri ea bongaka.Sebopeho sa eona se rarahaneng se fana ka menyetla ea nts'etsopele ea li-agent tse ncha tsa phekolo bakeng sa mafu a methapo, hammoho le lithethefatsi tse lebisang maloetse a fapaneng.Ka lipatlisiso tse eketsehileng le ho ntlafatsa, CPPMP e na le monyetla oa ho fana ka liphallelo tse kholo lefapheng la meriana le ho ntlafatsa liphello tsa mokuli.
